Something, in the lake of a small town, is killing innocent people.

A friend of John's calls Sam and Dean for help about a strange recording on the black box of a crashed plane. They soon realize that the demon which caused the crash is picking off the crash's only seven survivors.

The Winchester brothers enjoy Dean's new baby: a shiny newly restored car, while checking out a report of two recent human deaths and over a dozen split-open cows in the small town of Red Lodge, Montana. The local sheriff laughs at Sam and Dean's idea that a cult is behind it, claiming it happens naturally in the sun. But when Sam and Dean sneak into the morgue under false pretenses, they find a victim that has retractable vampire fangs. They catch demon hunter Gordon Walker, who claims to be a friend of their late father and having made both kills after six months of...

Dean and Sam assist Neil Levine, a heartbroken college kid who consoles his long-time crush after her breakup and then loses her in a car accident. Determined to have his feelings returned, Neil uses necromancy to bring her back from the dead. His efforts backfire when she returns as an angry and vengeful Zombie, forcing the brothers to stop her after she kills her boyfriend Matt and the girl he cheated on her with.

The Winchesters are called regarding a robbery of their father's storage unit, and track down the robbers to find the item stolen is a cursed rabbit's foot, which provides great luck until lost, and once lost the previous owner dies within a week. Sam picks up the foot and has great fortune, until it is pickpocketted away by the mercenary Bela. Dean must then get it back before Sam's bad luck gets him killed. To complicate the whole situation, Gordon, from his prison home, has convinced two other hunters that Sam is pure evil and must be killed.

The Winchester boys head to Ohio to research several deaths in a small town, where sin has taken a firm foothold on the population; prostitution, adultery, alcohol abuse, murder, and suicide are all prevalent in the once quiet town. Dean has a revealing conversation with a demon possessed woman. The demon Ruby assists Bobby in restoring the Colt to it's demon-killing grandeur.

Castiel sends Dean back in time to 1973 where he encounters younger versions of his parents and for the first time meets his grandfather Samuel Campbell who holds a secret that sheds a light on the Winchester Family's connection to the hunter community.

A hunter named Travis points Sam and Dean towards a meat eating creature called a Rugaru. Complicating matters is the fact that Travis's target is a normal suburban dad in the earlier process of changing and he hasn't killed anyone yet.

Not sure he trusts himself, Sam decides to give up hunting and goes off on his own. But that night, a late-night visitor tells Sam that he won't let him off the hook that easily. Dean, intent on stopping the Apocalypse, continues hunting on his own and teams up with Castiel to find the Archangel Raphael since Castiel believes Raphael knows the location of God's vessel on Earth.

Dean awakens five years in the future in an abandoned city and is attacked by humans infected with a demonic virus that makes them mindless, flesh-eating zombies. Zachariah soon appears and explains to Dean that the world he sees is the result of his refusal to help the angels fight Lucifer.

Sam calls Dean and asks him to head to Easter, Pennsylvania, to investigate the mysterious and gory death of two police officers. They visit the police officer Toby Grey that had witnessed the death of his partner and they learn that the three police officers had killed a teenager and planted a gun to justify their action. Then Toby dies in front of the Winchester brothers. They summon Castiel and they learn that the police officers were killed by Moses' staff. Further, Castiel tells that Heaven is chaotic and several lethal weapons have been stolen. They visit the ...

Bobby summons Crowley and finds that the demon has no intention of returning his soul and has given ten additional years of life for him. Meanwhile, Dean and Sam ask Bobby to advise which demon is killing people in Wisconsin, and after a long research, Bobby informs that is a Lamia. Then Rufus knocks on Bobby's door with the corpse of a demon Okami to bury it. However the demon is still alive and Bobby has to seek it out and vanquish the demon. Dean and Sam travel to Scotland and help Bobby to get his soul back. When Bobby is ready to eat a slice of the peach cobbler ...

Sam reunites with a childhood girlfriend who is supposedly preying on human brains.

Sam and Dean investigate murders of people who have their guilty pasts come back and kill them. Could Dean be next?

While trying to track down Kevin, Sam and Dean get sidetracked by a series of murders where the victims have gotten their hearts ripped out.

Sam and Dean come across a home made video of three friends whose lives are turned upside down by a werewolf.

Sam and Dean track down Castiel, while Bartholomew, a new leader of the fallen angels, tries to destroy him.

Sam and Dean accidentally free Dorothy, who has been trapped in the bunker for years, who seeks their help in killing the wicked witch.

Crowley is worried about Dean getting out of control, giving him a target to feed the mark. Sam struggles to escape from Cole. Hannah tries to convince Metatron to give Castiel's grace back.

Sam continues to try to save Dean from the Mark of Cain. Realizing that Dean's antics are causing problems for him in hell, Crowley seeks help from a reluctant Castiel.

Sam and Dean try to help Castiel recover from Rowena's spell, while searching for Amara who has now grown into a young girl. Rowena tries to use her powers to protect herself from the Winchesters, while Crowley tries to use Amara for his personal gain.

Sam and Dean's road trip to fight monsters and demons is chronicled entirely from the Impala's perspective.

When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel's hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.

Sam and Dean investigate a case that leads them to a devout religious family living off the grid. They realize the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary's latest decision.

A wraith kills her friend and Missouri enlists the help of Dean and Jody to protect her granddaughter, Patience, and could be next on the wraith's hit list. Sam continues to work with Jack to control his powers.

When multiple patients of grief counselor Mia Vallens turn up dead, Dean, Sam and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.

Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to be a father figure to Jack, who surprises even himself, when a life is on the line.

Dean continues to struggle, and then Sam has to think when action figures come to life and Dean finds himself inside a real life horror movie.